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Epigenomics refers to the systematic study of epigenetic modifications across the entire genome. Epigenetic modifications do not alter the primary DNA sequence, yet they regulate gene activities through chemical modifications, including DNA methylation, histone modifications and non-covalent RNA regulation. Based on high-throughput sequencing technologies, epigenomics characterizes epigenetic profiles of cells and tissues, and explores the epigenetic mechanisms underlying cell development and pathogenesis. Unlike genomics focusing on genomic DNA sequences, epigenomics centers on the regulatory effects of epigenetic modifications on gene expression.