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Biomolecular interactions constitute the fundamental mechanisms sustaining life. Within cells, proteins rarely function in isolation; instead, they operate through dynamic and specific interaction networks with diverse biomolecules. These interactions encompass the assembly of functional protein complexes (protein-protein), the reading and regulation of genetic information (protein-DNA), post-transcriptional modification and transport (protein-RNA), signal transduction and metabolic regulation (protein-small molecule), and structural support and functional synergy with other macromolecules (protein-macromolecule). Elucidating the molecular mechanisms, spatiotemporal dynamics, and functional consequences of these interactions is essential for understanding cellular signaling pathways, disease pathogenesis, and drug target discovery.