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Lysine pyruvylation (Kpy) is a metabolite-associated modification derived from pyruvate, a central intermediate of glycolysis. The transfer of pyruvoyl groups to lysine residues is mediated by acyltransferases such as p300 and HAT1, while SIRT3 contributes to the removal of this modification. Kpy has been implicated in the regulation of protein function and cellular processes associated with metabolic adaptation.