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Succinylation is an acylation modification involving the covalent attachment of a succinyl group to lysine residues. Compared with other lysine acylations, succinylation markedly alters the physicochemical properties of proteins, thereby influencing protein structure and function. Widely distributed in both histone and non-histone proteins, succinylation plays important roles in cellular metabolism, epigenetic regulation, and signal transduction.