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Target proteins refer to biological macromolecules, predominantly proteins, that can be specifically recognized and bound by drug molecules to elicit therapeutic effects. As the starting point for drug discovery, target proteins encompass a diverse range of functional classes, including classical enzymes, receptors, ion channels, and transporters. They play central roles in physiological processes such as signal transduction, metabolic regulation, and immune responses, with their dysfunction often serving as the molecular basis of diseases.

Based on their well-established disease associations, target proteins are essential tools in drug discovery and clinical diagnostics. In research workflows, recombinant target proteins are widely utilized for antibody screening (e.g., monoclonal/bispecific antibodies), CAR-T cell therapy target validation, and high-throughput drug screening model development. The scope of target proteins is extensive, encompassing well-studied immune checkpoints (e.g., PD-1) and cytokines, as well as hard-to-classify secreted regulatory proteins and intracellular signal transducers, serving as a bridge linking genomics to precision medicine.