Recombinant Human IL17RB Protein, C-His

Background:IL17RB(Interleukin-17 receptor B)is a receptor for the proinflammatory cytokines IL17B and IL17E. IL17RB is induced on human macrophages by IL4 and enhanced by TGFbeta.Human IL-17B R cDNA encodes a 502 amino acid (aa) residue type I membrane protein with a putative 17 aa signal peptide, a 275 aa extracellular domain, a 21 aa transmembrane domain and a 189 aa cytoplasmic tail.The protein Expressed in several endocrine tissues, mostly in fetal and adult liver, kidney, pancreas, testis, colon, brain and small intestine; not detected in peripheral blood leukocytes, lymphoid organs, and most cell lines.Diseases associated with IL17RB include Chronic Mucocutaneous Candidiasis and Seborrheic Infantile Dermatitis.It’s reported that IL17RB expression might predict prognosis and benefit from gemcitabine in patients with resectable pancreatic cancer.