Biotinylated Human IL17A & 17F Protein, C-Avi-His

Background:Human IL-17A&IL-17F is an disulfide-linked heterodimeric glycoprotein comprised of two members of the IL-17 family of cytokines, IL-17A and IL-17F .IL-17A and IL-17F bind to a receptor complex consisting of two IL-17RA chains and one IL-17RC subunit. Genes encoding IL-17A and IL-17F are located on chromosome 6 (6p12) and polymorphisms in these genes were studied in various autoimmune diseases. Previous studies have demonstrated that the G allele of the IL17A gene polymorphism is associated with significantly impaired long-term kidney allograft function and that the GA genotype of the IL17F gene polymorphism is associated with a significantly higher risk of a return to dialysis after kidney transplantation. It’s also reported that IL17A gene polymorphism was associated with significantly impaired long-term kidney allograft function, whereas the GA genotype of the IL17F gene polymorphism with a significantly higher risk of graft function loss and return to dialysis after kidney transplantation.