Recombinant Human IL31RA Protein, C-Fc

Background:The receptor for IL-31 consists of a heterodimer of IL-31 receptor α-chain (IL-31RA) and oncostatin M receptor β-chain (OSMR β). Intracellular signaling involving binding of the IL-31 receptor by IL-31 is mediated by the Janus kinase (JAK)-signal transducer and activator of transcription (STAT), phosphatidylinositol-3 kinase (PI3K)/AKT (also known as protein kinase B or PKB), and mitogen-activated protein kinase (MAPK) pathways. IL-31RA is expressed by immune cells such as activated macrophages, dendritic cells, eosinophils, and basophils, as well as by epidermal keratinocytes and cutaneous peripheral nerves.