Biotinylated Human IL17RE Protein, C-Fc-Avi

Background:Interleukin 17 Receptor E (IL-17 RE) is an approximately 70 kDa (predicted) transmembrane protein in the family of IL-17 receptors. IL-17 RE is expressed on keratinocytes, mucosal epithelial cells, Th17 cells, and gamma /δ T cells. It associates with the widely expressed IL-17 RA to form a heterodimeric receptor for IL-17C. IL-17C binds to IL-17 RE with high affinity and to IL-17 RA with low affinity. IL-17C expression is induced by inflammatory stimulation in colon and airway epithelial cells, keratinocytes, CD4+ T cells, macrophages, and dendritic cells. It is up regulated in various chronic inflammatory diseases including psoriasis, cystic fibrosis, and chronic obstructive pulmonary disease (COPD). IL-17 RE is reciprocally down regulated in psoriatic lesions. The interaction of IL-17C with IL-17 RE promotes mucosal immunity through the induction of anti bacterial peptides and pro inflammatory cytokines and chemokines. IL-17C action supports the integrity of the colon epithelium following infection induced damage but also contributes to psoriatic skin thickening and the progression of arthritis. IL-17C is additionally up regulated in Th17 cell dependent autoimmunity. In this setting, it exacerbates disease severity by inducing Th17 cell production of IL-17A, IL-17F, IL-22, CCR6, and CCL20. The up regulation of IL-17 RE in hepatocellular carcinoma is associated with poor prognosis.