Recombinant Human CD213a2/IL13RA2 Protein, C-Fc

Background:Interleukin-13 Receptor alpha 2 (IL-13 R alpha 2), also known as IL-13 binding protein, and CD213a2. IL-13RA2 is a transmembrane receptor which binds IL-13 with very high affinity. Due to its very short cytoplasmic region lacking signaling motifs, IL-13RA2 is generally thought to act primarily as a “decoy” receptor, sequestering IL-13 and thus preventing excessive IL-13 signaling via the complex IL-13RA1 and IL-4RA.In rodents, IL-13RA2 is released as a soluble factor and its expression correlates with a decreased responsiveness to IL-13 in chronic granulomatous inflammation in the liver, airway inflammation and airwayhyperreactivity, and immune and functional response to nematode infection.