Recombinant Human CD334/FGFR4 Protein, C-Fc

Background:Fibroblast growth factor receptor 4 (FGFR4) is a member of a highly conserved tyrosine kinase family, along with FGFR1–3. This family consists of an intracellular tyrosine kinase domain, a single transmembrane domain, and extracellular ligand binding domains. FGFRs have been reported to be involved in many physiological processes, including embryonic and postnatal development, metabolic homeostasis, and tissue maintenance and repair. FGFR4 is widely expressed in the embryonic stage, functioning in tissue differentiation and organogenesis. The expression of FGFR4 is restrained to actively growing tissue, such as liver, lung and bone, with functions in regulating bile acid production, metabolism, muscle differentiation, and tissue repair.