Recombinant Mouse TNFSF12/TWEAK protein, C-His

Recombinant Mouse TNFSF12/TWEAK protein, C-His
Recombinant Mouse TNFSF12/TWEAK protein, C-His
$290.00
Size:20μg
SKU: PR16974-20μg

Catalog No.: PR16974

Specification: 20ug/100ug/500ug/1mg

Stock: In stock

Product details, specifications, documents, and related products are available from the catalog record. Learn more

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Product information

Product detailsSpecificationsQ & AEducation

Background:TNF-related Weak Inducer of Apoptosis (TWEAK) is a type II membrane protein of the tumor necrosis factor (TNF) family members, high levels expression in mouse peritoneal macrophages. The murine and human TWEAK homologs are very close related (~93% sequence identity in the receptor-binding domain). TWEAK is a 17.3 kDa protein containing 129 residues. TWEAK induce apoptosis through cognate receptor Fn14 activate caspase-8 and caspase-3, in HSC3 cells KATO-III gastric adenocarcinoma cells and IFN-γ-treated HT-29. TWEAK stimulate inflammatory cytokines in HT-29, A375 cells, WI-38 fibroblast sand astrocytes.

Product Overview

Catalog No.
PR16974
SKU
PR16974-20μg
Category
Tumor Necrosis Factors
Product Type
Other
Size
20ug/100ug/500ug/1mg
Stock Status
In stock
Available Stock
20
Minimum Order Quantity
1

Storage & Compliance

Research Use Only
Yes

Additional Specifications

Molecule
TNFSF12/TWEAK
Background
TNF-related Weak Inducer of Apoptosis (TWEAK) is a type II membrane protein of the tumor necrosis factor (TNF) family members, high levels expression in mouse peritoneal macrophages. The murine and human TWEAK homologs are very close related (~93% sequence identity in the receptor-binding domain). TWEAK is a 17.3 kDa protein containing 129 residues. TWEAK induce apoptosis through cognate receptor Fn14 activate caspase-8 and caspase-3, in HSC3 cells KATO-III gastric adenocarcinoma cells and IFN-γ-treated HT-29. TWEAK stimulate inflammatory cytokines in HT-29, A375 cells, WI-38 fibroblast sand astrocytes.
Species
Mouse
Source
E. coli
Tags
C-6His
Accession
O54907
KnownAs
TNFSF12, DR3LG, Apo3 Ligand, AI255180, C87282, Fn1, Fn14, HPIP, TWEAK-R, Twea, TweakR, Tnfrsf12a
Protein Length
His110-His249
Predicted Molecular Mass
18.14 kDa
N-terminal Sequence
--
SDS-PAGE
17-25 kDa, reducing condition
Endotoxin
<0.1 EU/µg as determined by LAL test.
Concentration
--
Purity-SDS-PAGE
>98% as determined by SDS-PAGE.
Purity-SEC-HPLC
--
Activity
--
Form
Lyophilized
Formulation
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Shipping
The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.
Storage
Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3-6 months. Please minimize freeze-thaw cycles and use a manual defrost freezer.
Reconstitution
Reconstitute the lyophilized protein in sterile water at a concentration of greater than 100 µg/mL, and incubate the stock solution at room temperature for at least 20 mins to ensure sufficient re-dissolved. Do Not Vortex! Vigorous shaking may impair the biological activity of the protein.

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Documents

Datasheet, COA, SDS, and protocol files can be requested from technical support.

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Keywords:Tumor Necrosis Factors