U-Blot® Smad2 Rabbit mAb

Name: U-Blot® Smad2 Rabbit mAb
SKU: WR4044
Availability: InStock

$268.00

Size:50μL

SKU: WR4044-50

Catalog No.: WR4044

Specification: 50μL/100μL

Stock: In stock

U-Blot® Smad2 Rabbit mAb Learn more

Product details Specifications Q & A Education

Background:The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation

Product Overview

Catalog No.: WR4044
SKU: WR4044-50
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: PKC α
Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF,IP,ELISA
MW(Calculated): 77kD
MW(Observed): 77kD
Host Species: Rabbit
Isotype: IgG,Kappa
Conjugate: Phospho
Modification: Thr638
Recommended Dilution Ratio: IHC 1:1000-1:4000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
Composition: PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source: --
Purification Process: Protein A
Purity: --
Storage Condition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: --
Clonality: Monoclonal
Clone Number: PT0727R
Immunogen: --
Sequence: --
Specificity: Phospho-PKC α (T638) Antibody detects endogenous levels of PKC α protein only when phosphorylated at T638.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):VLtPP
Gene Name: PRKCA
Protein Name: Protein kinase C alpha type
Alias: PRKCA;PKCA;PRKACA;Protein kinase C alpha type;PKC-A;PKC-alpha
Organism-1: Human
Gene ID-1: 5578
SwissProt-1: P17252
Organism-2: Mouse
Gene ID-2: 18750
SwissProt-2: P20444
Organism-3: Rat
Gene ID-3: --
SwissProt-3: P05696
Organism-4: --
Gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm . Cell membrane ; Peripheral membrane protein . Mitochondrion membrane ; Peripheral membrane protein . Nucleus .