U-Blot® Research Grade Cibotercept

Name: U-Blot® Research Grade Cibotercept
SKU: WA2598
Availability: InStock

$9,999.00

Size:50ug

SKU: WA2598-50

Catalog No.: WA2598

Specification: 50ug/100ug

Stock: In stock

U-Blot® Research Grade Cibotercept Learn more

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U-Blot® Research Grade Cibotercept

Product Overview

Catalog No.: WA2598
SKU: WA2598-50
Category: Biosimilar Antibodies
Product Type: Other
Size: 50ug/100ug
Stock Status: In stock
Available Stock: 999
Minimum Order Quantity: 1

Storage & Compliance

Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Research Use Only: Yes

Additional Specifications

PackSize: 50ug/100ug
Target: ACTR-IIB
Reactivity: Human
Applications: ELISA, Functional assay, Research in vivo
Host Species: Mammalian Cells
Isotype: Human ACTR-IIB extracellular domain (ECD) fragment fused via the peptide linker to a human IgG1 Fc fragment
Conjugate/Modification: --
Recommended Dilution Ratio: --
Composition: 0.01M PBS, pH 7.4.
Purification Process: Protein A/G purified from cell culture supernatant.
Purity: >95% purity as determined by SDS-PAGE.
storageCondition: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Clonality: --
Clone Number: --
Immunogen: Mammalian Cells
Alias: ACTR-IIB, Activin receptor type IIB, Activin receptor type-2B, ACVR2B
Species: --
Gene ID-1: Q13705
Uniprot: --
Background: Cibotercept is an anti-MSTN/INHBA/GDF11 monoclonal antibody. • LncRNA ACVR2B-as1 interacts with ALDOA to regulate the self-renewal and apoptosis of human spermatogonial stem cells by controlling glycolysis activity., PMID:39254854 • Epistasis between polymorphisms in ACVR2B and ADAMTS19 is associated with premature ovarian failure., PMID:25051287 • ACVR2B/Fc counteracts chemotherapy-induced loss of muscle and bone mass., PMID:29089584 • Activin A and Acvr2b mRNA from Umbilical Cord Blood Are Not Reliable Markers of Mild or Moderate Neonatal Hypoxic-Ischemic Encephalopathy., PMID:33706404 • Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B., PMID:26047946 • iMSC-mediated delivery of ACVR2B-Fc fusion protein reduces heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva., PMID:38500216 • BMPR2 inhibits activin and BMP signaling via wild-type ALK2., PMID:29739878 • Circ_0000566 contributes oxygen-glucose deprivation and reoxygenation (OGD/R)-induced human brain microvascular endothelial cell injury via regulating miR-18a-5p/ACVR2B axis., PMID:36781583 • Muscle and serum metabolomes are dysregulated in colon-26 tumor-bearing mice despite amelioration of cachexia with activin receptor type 2B ligand blockade., PMID:30860875 • Antibody-based strategies for the detection of Luspatercept (ACE-536) in human serum., PMID:28929587
Tissue Expression: --
Signaling_pathway: --
Research Areas: --

Tech Support

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Documents

Datasheet, COA, SDS, and protocol files can be requested from technical support.

Storage & Handling

Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.