U-Blot® Research Grade Elritercept

Name: U-Blot® Research Grade Elritercept
SKU: WA2770
Availability: InStock

$9,999.00

Size:50ug

SKU: WA2770-50

Catalog No.: WA2770

Specification: 50ug/100ug

Stock: In stock

U-Blot® Research Grade Elritercept Learn more

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U-Blot® Research Grade Elritercept

Product Overview

Catalog No.: WA2770
SKU: WA2770-50
Category: Biosimilar Antibodies
Product Type: Other
Size: 50ug/100ug
Stock Status: In stock
Available Stock: 999
Minimum Order Quantity: 1

Storage & Compliance

Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Research Use Only: Yes

Additional Specifications

PackSize: 50ug/100ug
Target: ACVR2
Reactivity: Human
Applications: ELISA, Functional assay, Research in vivo
Host Species: Human
Isotype: Fusion-[human activin receptor type 2-A (activin receptor type IIA, ACTR-IIA) extracellular domain (ECD) fragment (1-109) engineered varian]2-IgG1-Fc (Fragment constant)
Conjugate/Modification: --
Recommended Dilution Ratio: --
Composition: 0.01M PBS, pH 7.4.
Purification Process: Purified by Nickel column.
Purity: >95% purity as determined by SDS-PAGE.
storageCondition: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Clonality: Monoclonal
Clone Number: --
Immunogen: Mammalian Cells
Alias: ACVR2, ACTRIIA, ACTR-IIA, Activin receptor type IIA, ACVR2A, Activin receptor type-2A
Species: --
Gene ID-1: P27037
Uniprot: --
Background: Elritercept (KER-050) is a recombinant fusion protein comprising a modified activin receptor type IIA extracellular domain fused to a human IgG1 Fc. Elritercept inhibits activin A and other select TGF-β superfamily ligands. • Activin receptor type 2A (ACVR2A) functions directly in osteoblasts as a negative regulator of bone mass., PMID:28659341 • Activin a Receptor Type 2A Mutation Affects the Tumor Biology of Microsatellite Instability-High Gastric Cancer., PMID:33420656 • Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis., PMID:34099644 • Gene expression and silencing of activin receptor type 2A (ACVR2A) in myoblast cells of chicken., PMID:27635666 • Type II BMP and activin receptors BMPR2 and ACVR2A share a conserved mode of growth factor recognition., PMID:35643319 • Murine FSH Production Depends on the Activin Type II Receptors ACVR2A and ACVR2B., PMID:32270195 • The m6A methyltransferase METTL3 regulates muscle maintenance and growth in mice., PMID:35013323 • Activin A/ACVR2A axis inhibits epithelial-to-mesenchymal transition in colon cancer by activating SMAD2., PMID:37378449 • Adenovirus‑mediated knockdown of activin A receptor type 2A attenuates immune‑induced hepatic fibrosis in mice and inhibits interleukin‑17‑induced activation of primary hepatic stellate cells., PMID:29620144 • A molecular study of synovial chondromatosis., PMID:31589790
Tissue Expression: --
Signaling_pathway: --
Research Areas: --

Tech Support

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Documents

Datasheet, COA, SDS, and protocol files can be requested from technical support.

Storage & Handling

Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.