U-Blot® Research Grade Emapalumab

Name: U-Blot® Research Grade Emapalumab
SKU: WA2776
Availability: InStock

$9,999.00

Size:50ug

SKU: WA2776-50

Catalog No.: WA2776

Specification: 50ug/100ug

Stock: In stock

U-Blot® Research Grade Emapalumab Learn more

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U-Blot® Research Grade Emapalumab

Product Overview

Catalog No.: WA2776
SKU: WA2776-50
Category: Biosimilar Antibodies
Product Type: Other
Size: 50ug/100ug
Stock Status: In stock
Available Stock: 999
Minimum Order Quantity: 1

Storage & Compliance

Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Research Use Only: Yes

Additional Specifications

PackSize: 50ug/100ug
Target: Interferon gamma
Reactivity: Human
Applications: ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host Species: Human
Isotype: IgG1-lambda
Conjugate/Modification: --
Recommended Dilution Ratio: --
Composition: 0.01M PBS, pH 7.4.
Purification Process: Protein A/G purified from cell culture supernatant.
Purity: >95% purity as determined by SDS-PAGE.
storageCondition: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Clonality: Monoclonal
Clone Number: --
Immunogen: Mammalian Cells
Alias: Interferon gamma, IFN-gamma, Immune interferon, IFNG
Species: --
Gene ID-1: P01579
Uniprot: --
Background: Emapalumab (NI-0501) is a human monoclonal IgG1 antibody that noncompetitively inhibits IFN-γ. Emapalumab binds with high affinity (Kd= 1.4 pM) to both free IFN-γ as well as IFN-γ bound to its receptor. Emapalumab can be used in research of hemophagocytic lymphohistiocytosis (HLH). • Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation., PMID:33606996 • Dysregulation in IFN-γ signaling and response: the barricade to tumor immunotherapy., PMID:37275859 • IFN-γ drives inflammatory bowel disease pathogenesis through VE-cadherin-directed vascular barrier disruption., PMID:31566580 • IFN-γ Contributes to the Immune Mechanisms of Hypertension., PMID:36591357 • Liver type 1 innate lymphoid cells develop locally via an interferon-γ-dependent loop., PMID:33766856 • Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche., PMID:29950724 • IRAK1-regulated IFN-γ signaling induces MDSC to facilitate immune evasion in FGFR1-driven hematological malignancies., PMID:34906138 • Interferon-gamma release assay performance in northeastern Brazil: influence of the IFNG+874 A>T polymorphism., PMID:29787713 • Restraint of IFN-γ expression through a distal silencer CNS-28 for tissue homeostasis., PMID:37040761 • MUC1-C integrates activation of the IFN-γ pathway with suppression of the tumor immune microenvironment in triple-negative breast cancer., PMID:33495298
Tissue Expression: --
Signaling_pathway: --
Research Areas: --

Tech Support

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Documents

Datasheet, COA, SDS, and protocol files can be requested from technical support.

Storage & Handling

Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.