U-Blot® Research Grade Empasiprubart

Name: U-Blot® Research Grade Empasiprubart
SKU: WA2784
Availability: InStock

$9,999.00

Size:50ug

SKU: WA2784-50

Catalog No.: WA2784

Specification: 50ug/100ug

Stock: In stock

U-Blot® Research Grade Empasiprubart Learn more

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U-Blot® Research Grade Empasiprubart

Product Overview

Catalog No.: WA2784
SKU: WA2784-50
Category: Biosimilar Antibodies
Product Type: Other
Size: 50ug/100ug
Stock Status: In stock
Available Stock: 999
Minimum Order Quantity: 1

Storage & Compliance

Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Research Use Only: Yes

Additional Specifications

PackSize: 50ug/100ug
Target: Complement C2
Reactivity: Human
Applications: ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host Species: Human
Isotype: IgG1-kappa
Conjugate/Modification: --
Recommended Dilution Ratio: --
Composition: 0.01M PBS, pH 7.4.
Purification Process: Protein A/G purified from cell culture supernatant.
Purity: >95% purity as determined by SDS-PAGE.
storageCondition: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Clonality: Monoclonal
Clone Number: --
Immunogen: Mammalian Cells
Alias: Complement C2, C2, C3/C5 convertase
Species: --
Gene ID-1: P06681
Uniprot: --
Background: Empasiprubar (ARGX-117) is a humanized inhibitory monoclonal antibody targeting complement C2. Empasiprubar binds to the Sushi-2 domain of C2, preventing the formation of C3 pre convertase and inhibiting the activation of classical and lectin pathways upstream of C3 activation. Empasiprubar can prevent complement mediated autoimmune hemolytic anemia and antibody mediated organ transplant rejection. Empasiprubar can prevent neuroglial lymphoconjunctival injury in GM1 antibody mediated mouse models. • Granzyme K activates the entire complement cascade., PMID:39914456 • Granzyme K drives a newly-intentified pathway of complement activation., PMID:38826230 • Plasmin as a complement C5 convertase., PMID:27077104 • Inhibition of the alternative C3 convertase and classical C5 convertase of complement by group A streptococcal M protein., PMID:2142480 • Formation of high affinity C5 convertase of the classical pathway of complement., PMID:12878586 • The structure of C2b, a fragment of complement component C2 produced during C3 convertase formation., PMID:19237749 • Modulation of classical C3 convertase of complement by tear lactoferrin., PMID:6922088 • Inhibition of c3 convertase activity by hepatitis C virus as an additional lesion in the regulation of complement components., PMID:24983375 • MASP-2, the C3 convertase generating protease of the MBLectin complement activating pathway., PMID:9777418 • The human complement system: assembly of the classical pathway C3 convertase., PMID:6906228
Tissue Expression: --
Signaling_pathway: --
Research Areas: --

Tech Support

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Documents

Datasheet, COA, SDS, and protocol files can be requested from technical support.

Storage & Handling

Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.