U-Blot® Research Grade Ontorpacept

Name: U-Blot® Research Grade Ontorpacept
SKU: WA3290
Availability: InStock

$9,999.00

Size:50ug

SKU: WA3290-50

Catalog No.: WA3290

Specification: 50ug/100ug

Stock: In stock

U-Blot® Research Grade Ontorpacept Learn more

Product details Specifications Q & A Education

U-Blot® Research Grade Ontorpacept

Product Overview

Catalog No.: WA3290
SKU: WA3290-50
Category: Biosimilar Antibodies
Product Type: Other
Size: 50ug/100ug
Stock Status: In stock
Available Stock: 999
Minimum Order Quantity: 1

Storage & Compliance

Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Research Use Only: Yes

Additional Specifications

PackSize: 50ug/100ug
Target: CD47
Reactivity: Human
Applications: ELISA, Functional assay, Research in vivo
Host Species: Mammalian Cells
Isotype: Fusion - SIRPA (signal regulatory protein alpha, SHPS1, SIRP, SIRPalpha) - IGHG1 (Fc (Fragment constant)
Conjugate/Modification: --
Recommended Dilution Ratio: --
Composition: 0.01M PBS, pH 7.4.
Purification Process: Protein A/G purified from cell culture supernatant.
Purity: >95% purity as determined by SDS-PAGE.
storageCondition: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Clonality: --
Clone Number: --
Immunogen: Mammalian Cells
Alias: Leukocyte surface antigen CD47, CD47, Antigenic surface determinant protein OA3, IAP, Integrin-associated protein, Protein MER6, MER6
Species: --
Gene ID-1: Q08722
Uniprot: --
Background: Magrolimab is a first-in-class investigational monoclonal antibody against CD47 and macrophage checkpoint inhibitor that is designed to interfere with recognition of CD47 by the SIRPα receptor on macrophages, thus blocking the • Isolation and characterization of CD47 glycoprotein: a multispanning membrane protein which is the same as integrin-associated protein (IAP) and the ovarian tumour marker OA3., PMID:7998989 • Integrin-associated protein (CD47) and its ligands., PMID:11306274 • Integrin-associated protein (CD47/IAP) contributes to T cell arrest on inflammatory vascular endothelium under flow., PMID:11156950 • Rh-related antigen CD47 is the signal-transducer integrin-associated protein., PMID:8294396 • Membrane mobility and clustering of Integrin Associated Protein (IAP, CD47)--major differences between mouse and man and implications for signaling., PMID:16697668 • Integrin-associated protein/CD47 regulates motile activity in human B-cell lines through CDC42., PMID:10891456 • Integrin-associated protein (CD47) is a comitogenic molecule on CD3-activated human T cells., PMID:8992983 • Molecular cloning and functional characterization of the pig homologue of integrin-associated protein (IAP/CD47)., PMID:12153520 • Thrombospondin-bound integrin-associated protein (CD47) physically and functionally modifies integrin alphaIIbbeta3 by its extracellular domain., PMID:12736272 • The thrombospondin receptor integrin-associated protein (CD47) functionally couples to heterotrimeric Gi., PMID:10085089
Tissue Expression: --
Signaling_pathway: --
Research Areas: --

Tech Support

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Documents

Datasheet, COA, SDS, and protocol files can be requested from technical support.

Storage & Handling

Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.