U-Blot® Research Grade Prasinezumab

Name: U-Blot® Research Grade Prasinezumab
SKU: WA3389
Availability: InStock

$9,999.00

Size:50ug

SKU: WA3389-50

Catalog No.: WA3389

Specification: 50ug/100ug

Stock: In stock

U-Blot® Research Grade Prasinezumab Learn more

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U-Blot® Research Grade Prasinezumab

Product Overview

Catalog No.: WA3389
SKU: WA3389-50
Category: Biosimilar Antibodies
Product Type: Other
Size: 50ug/100ug
Stock Status: In stock
Available Stock: 999
Minimum Order Quantity: 1

Storage & Compliance

Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Research Use Only: Yes

Additional Specifications

PackSize: 50ug/100ug
Target: Alpha-synuclein
Reactivity: Human
Applications: ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host Species: Humanized
Isotype: IgG1-kappa
Conjugate/Modification: --
Recommended Dilution Ratio: --
Composition: 0.01M PBS, pH 7.4.
Purification Process: Protein A/G purified from cell culture supernatant.
Purity: >95% purity as determined by SDS-PAGE.
storageCondition: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Clonality: Monoclonal
Clone Number: --
Immunogen: Mammalian Cells
Alias: Alpha-synuclein, PARK1, Non-A4 component of amyloid precursor, NACP, Non-A beta component of AD amyloid, SNCA
Species: --
Gene ID-1: P37840
Uniprot: --
Background: Cinpanemab is a human-derived monoclonal antibody directed against α-synuclein. Genetic and pathology evidence implicate this protein in the molecular pathogenesis of Parkinson's disease (PD) and other α-synucleinopathies such as dementia with Lewy bodies (DLB). In 2010, Biogen licensed cinpanemab from Neurimmune. The antibody was generated with reverse translational medicine technology from naturally occurring, presumably protective antibodies found in healthy aged donors, as were aducanumab and other antibodies in the Biogen-Neurimmune partnership. The antibody, previously known as BIIB054, binds to α-synuclein residues 1-10, with 800-fold higher affinity for aggregated over monomeric α-synuclein. The antibody inhibits α-synuclein spreading in cell-based assays, and slows pathology and motor symptoms in mice (Weihofen et al., 2019). • Direct evidence for ultrastructures of the α-synuclein-associated synaptic vesicle pool in presynaptic terminals., PMID:39233262 • Progress in the pathogenesis and genetics of Parkinson's disease., PMID:18426756 • Genetics of Parkinson disease., PMID:15717024 • [Genetic factors associated with dementia in Parkinson's disease (PD)]., PMID:25739491 • Analysis of GWAS-linked loci in Parkinson disease reaffirms PARK16 as a susceptibility locus., PMID:20697102 • Molecular findings in familial Parkinson disease in Spain., PMID:12056932 • Are genetic and sporadic Parkinson's disease patients equally susceptible to develop dementia?, PMID:19740488 • Caenorhabditis elegans as an experimental tool for the study of complex neurological diseases: Parkinson's disease, Alzheimer's disease and autism spectrum disorder., PMID:22068627 • TRAF6 promotes atypical ubiquitination of mutant DJ-1 and alpha-synuclein and is localized to Lewy bodies in sporadic Parkinson's disease brains., PMID:20634198 • Positron emission tomography changes in PARK1 mutation., PMID:16211612
Tissue Expression: --
Signaling_pathway: --
Research Areas: --

Tech Support

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Documents

Datasheet, COA, SDS, and protocol files can be requested from technical support.

Storage & Handling

Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.