- PackSize
- 50ug/100ug
- Target
- NGF/Beta-NGF
- Reactivity
- Dog
- Applications
- ELISA, Bioactivity: FACS, Functional assay, Research in vivo
- Host Species
- Caninized
- Isotype
- IgG1, kappa
- Conjugate/Modification
- --
- Recommended Dilution Ratio
- --
- Composition
- 0.01M PBS, pH 7.4.
- Purification Process
- Protein A/G purified from cell culture supernatant.
- Purity
- >95% purity as determined by SDS-PAGE.
- storageCondition
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
- Clonality
- Monoclonal
- Clone Number
- --
- Immunogen
- Mammalian Cells
- Alias
- NGF/Beta-NGF
- Species
- --
- Gene ID-1
- F1PDQ3
- Uniprot
- --
- Background
- Bedinvetmab (ZTS-00508841) is a canine monoclonal antibody (mAb) targeting nerve growth factor (NGF). Bedinvetmab inhibits NGF interaction with tropomyosin receptor kinase A (trkA) and p75 neurotrophin receptor (p75NTR) receptors. Bedinvetmab can be used for the research of osteoarthritis pain in dogs.<br>• Encapsulation of β-NGF in injectable microrods for localized delivery accelerates endochondral fracture repair., PMID:37284244<br/>• New insights of the role of β-NGF in the ovulation mechanism of induced ovulating species., PMID:30763273<br/>• Effect of the Camelid's Seminal Plasma Ovulation-Inducing Factor/β-NGF: A Kisspeptin Target Hypothesis., PMID:28713816<br/>• β-NGF and β-NGF receptor upregulation in blood and synovial fluid in osteoarthritis., PMID:28253191<br/>• The β-NGF/TrkA Signalling Pathway Is Associated With the Production of Anti-Nucleoprotein IgG in Convalescent COVID-19., PMID:35095908<br/>• HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy., PMID:38646645<br/>• Heterologous beta-nerve growth factor (β-NGF) given at the LH surge enhances luteal function in dairy heifers., PMID:34186420<br/>• β-NGF Stimulates Steroidogenic Enzyme and <i>VEGFA</i> Gene Expression, and Progesterone Secretion via ERK 1/2 Pathway in Primary Culture of Llama Granulosa Cells., PMID:33195615<br/>• Ovulation mechanism in South American Camelids: The active role of β-NGF as the chemical signal eliciting ovulation in llamas and alpacas., PMID:32088046<br/>• Astragaloside‑IV modulates NGF‑induced osteoblast differentiation via the GSK3β/β‑catenin signalling pathway., PMID:33179111<br/>
- Tissue Expression
- --
- Signaling_pathway
- --
- Research Areas
- --