U-Blot® Btk Monoclonal Antibody

Name: U-Blot® Btk Monoclonal Antibody
SKU: WM0065
Availability: InStock

$268.00

Size:50μL

SKU: WM0065-50

Catalog No.: WM0065

Specification: 50μL/100μL

Stock: In stock

U-Blot® Btk Monoclonal Antibody Learn more

Product details Specifications Q & A Education

Background：The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013],

Product Overview

Catalog No.: WM0065
SKU: WM0065-50
Category: Mouse mAbs
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: Btk
Reactivity: Human,Monkey
Application: WB,IHC,IF,ELISA
MW(Calculated): 76kD
MW(Observed): --
Host Species: Mouse
Isotype: --
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:500-1:2000;IHC 1:200-1:1000;IF 1:200-1:1000;ELISA 1:10000;Not yet tested in other applications.
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: Affinity purification
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: --
Clonality: Monoclonal
Clone No.: --
Immunogen: Purified recombinant fragment of Btk expressed in E. Coli.
Sequence: --
Specificity: Btk Monoclonal Antibody detects endogenous levels of Btk protein.
Gene Name: BTK
Protein Name: Tyrosine-protein kinase BTK
Other Name: BTK;AGMX1;ATK;BPK;Tyrosine-protein kinase BTK;Agammaglobulinaemia tyrosine kinase;ATK;B-cell progenitor kinase;BPK;Bruton tyrosine kinase
Organism-1: Human
Gene ID-1: 695
SwissProt-1: Q06187
Organism-2: Mouse
Gene ID-2: --
SwissProt-2: P35991
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. In steady state, BTK is predominantly cytosolic. Following B-cell receptor (BCR) engagement by antigen, translocates to the plasma membrane through its PH domain. Plasma membrane localization is a critical step in the activation of BTK. A fraction of BTK also shuttles between the nucleus and the cytoplasm, and nuclear export is mediated by the nuclear export receptor CRM1.