U-Blot® IL-1α Monoclonal Antibody

Name: U-Blot® IL-1α Monoclonal Antibody
SKU: WM0260
Availability: InStock

$268.00

Size:50μL

SKU: WM0260-50

Catalog No.: WM0260

Specification: 50μL/100μL

Stock: In stock

U-Blot® IL-1α Monoclonal Antibody Learn more

Product details Specifications Q & A Education

Background：The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008],

Product Overview

Catalog No.: WM0260
SKU: WM0260-50
Category: Mouse mAbs
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: IL-1α
Reactivity: Human
Application: WB,ELISA
MW(Calculated): 31kD
MW(Observed): --
Host Species: Mouse
Isotype: --
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: Affinity purification
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: --
Clonality: Monoclonal
Clone No.: --
Immunogen: Purified recombinant fragment of human IL-1a expressed in E. Coli.
Sequence: --
Specificity: IL-1α Monoclonal Antibody detects endogenous levels of IL-1α protein.
Gene Name: IL1A
Protein Name: Interleukin-1 alpha
Other Name: IL1A;IL1F1;Interleukin-1 alpha;IL-1 alpha;Hematopoietin-1
Organism-1: Human
Gene ID-1: 3552
SwissProt-1: P01583
Organism-2: Mouse
Gene ID-2: --
SwissProt-2: P01582
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm . Secreted . The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). .