U-Blot® LIN-28 Monoclonal Antibody

Name: U-Blot® LIN-28 Monoclonal Antibody
SKU: WM0298
Availability: InStock

$268.00

Size:50μL

SKU: WM0298-50

Catalog No.: WM0298

Specification: 50μL/100μL

Stock: In stock

U-Blot® LIN-28 Monoclonal Antibody Learn more

Product details Specifications Q & A Education

Background：This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of microRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with cancer progression in multiple tissues. [provided by RefSeq, Sep 2015],

Product Overview

Catalog No.: WM0298
SKU: WM0298-50
Category: Mouse mAbs
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: LIN28A
Reactivity: Human
Application: WB,IF,ELISA
MW(Calculated): 23kD
MW(Observed): --
Host Species: Mouse
Isotype: --
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:10000;Not yet tested in other applications.
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: Affinity purification
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: --
Clonality: Monoclonal
Clone No.: --
Immunogen: Purified recombinant fragment of LIN-28 (aa93-209) expressed in E. Coli.
Sequence: --
Specificity: LIN-28 Monoclonal Antibody detects endogenous levels of LIN-28 protein.
Gene Name: LIN28A
Protein Name: Protein lin-28 homolog A
Other Name: CSDD1;FLJ12457;LIN 28;Lin-28A;LIN28;LIN28A;LN28A_HUMAN;Protein lin-28 homolog A;ZCCHC1;Zinc finger CCHC domain-containing protein 1.
Organism-1: Human
Gene ID-1: 79727
SwissProt-1: Q9H9Z2
Organism-2: Mouse
Gene ID-2: --
SwissProt-2: Q8K3Y3
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm . Rough endoplasmic reticulum . Cytoplasm, P-body . Cytoplasm, Stress granule . Nucleus, nucleolus . Predominantly cytoplasmic (PubMed:22118463). In the cytoplasm, localizes to peri-endoplasmic reticulum regions and detected in the microsomal fraction derived from rough endoplasmic reticulum (RER) following subcellular fractionation. May be bound to the cytosolic surface of RER on which ER-associated mRNAs are translated (By similarity). Shuttle from the nucleus to the cytoplasm requires RNA-binding (PubMed:17617744). Nucleolar localization is observed in 10-15% of the nuclei in differentiated myotubes (By similarity). .