U-Blot® PRAK Monoclonal Antibody

Name: U-Blot® PRAK Monoclonal Antibody
SKU: WM0381
Availability: InStock

$268.00

Size:50μL

SKU: WM0381-50

Catalog No.: WM0381

Specification: 50μL/100μL

Stock: In stock

U-Blot® PRAK Monoclonal Antibody Learn more

Product details Specifications Q & A Education

Background：The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012],

Product Overview

Catalog No.: WM0381
SKU: WM0381-50
Category: Mouse mAbs
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: MAPKAPK5
Reactivity: Human
Application: WB,IHC,IF,ELISA
MW(Calculated): 54kD
MW(Observed): --
Host Species: Mouse
Isotype: --
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:500-1:2000;IHC 1:200-1:1000;ELISA 1:10000;IF 1:50-200
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: Affinity purification
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: --
Clonality: Monoclonal
Clone No.: --
Immunogen: Purified recombinant fragment of PRAK expressed in E. Coli.
Sequence: --
Specificity: PRAK Monoclonal Antibody detects endogenous levels of PRAK protein.
Gene Name: MAPKAPK5
Protein Name: MAP kinase-activated protein kinase 5
Other Name: MAPKAPK5;PRAK;MAP kinase-activated protein kinase 5;MAPK-activated protein kinase 5;MAPKAP kinase 5;MAPKAP-K5;MAPKAPK-5;MK-5;MK5;p38-regulated/activated protein kinase;PRAK
Organism-1: Human
Gene ID-1: 8550
SwissProt-1: Q8IW41
Organism-2: Mouse
Gene ID-2: --
SwissProt-2: O54992
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm. Nucleus. Translocates to the cytoplasm following phosphorylation and activation. Interaction with ERK3/MAPK6 or ERK4/MAPK4 and phosphorylation at Thr-182, activates the protein kinase activity, followed by translocation to the cytoplasm. Phosphorylation by PKA/PRKACA at Ser-115 also induces nuclear export.