U-Blot® TLR2 Monoclonal Antibody

Name: U-Blot® TLR2 Monoclonal Antibody
SKU: WM0445
Availability: InStock

$268.00

Size:50μL

SKU: WM0445-50

Catalog No.: WM0445

Specification: 50μL/100μL

Stock: In stock

U-Blot® TLR2 Monoclonal Antibody Learn more

Product details Specifications Q & A Education

Background：The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016],

Product Overview

Catalog No.: WM0445
SKU: WM0445-50
Category: Mouse mAbs
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: TLR2
Reactivity: Human
Application: WB,ELISA
MW(Calculated): 90kD
MW(Observed): --
Host Species: Mouse
Isotype: --
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: Affinity purification
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: --
Clonality: Monoclonal
Clone No.: --
Immunogen: Purified recombinant fragment of human TLR2 expressed in E. Coli.
Sequence: --
Specificity: TLR2 Monoclonal Antibody detects endogenous levels of TLR2 protein.
Gene Name: TLR2
Protein Name: Toll-like receptor 2
Other Name: TLR2;TIL4;Toll-like receptor 2;Toll/interleukin-1 receptor-like protein 4;CD antigen CD282
Organism-1: Human
Gene ID-1: 7097
SwissProt-1: O60603
Organism-2: Mouse
Gene ID-2: --
SwissProt-2: Q9QUN7
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Membrane ; Single-pass type I membrane protein . Cytoplasmic vesicle, phagosome membrane ; Single-pass type I membrane protein . Membrane raft . Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to diacylated lipoproteins, TLR2:TLR6 heterodimers are recruited in lipid rafts, this recruitment determines the intracellular targeting to the Golgi apparatus. Triacylated lipoproteins induce the same mechanism for TLR2:TLR1 heterodimers. .