U-Blot® BACE Monoclonal Antibody

Name: U-Blot® BACE Monoclonal Antibody
SKU: WM0478
Availability: InStock

$268.00

Size:50μL

SKU: WM0478-50

Catalog No.: WM0478

Specification: 50μL/100μL

Stock: In stock

U-Blot® BACE Monoclonal Antibody Learn more

Product details Specifications Q & A Education

Background：beta-secretase 1(BACE1) Homo sapiens This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq, Nov 2015],

Product Overview

Catalog No.: WM0478
SKU: WM0478-50
Category: Mouse mAbs
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: BACE
Reactivity: Human,Rat,Bovine,Dog,Pig
Application: WB
MW(Calculated): 56kD
MW(Observed): --
Host Species: Mouse
Isotype: --
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:1000-1:2000;Not yet tested in other applications.
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: Affinity purification
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: --
Clonality: Monoclonal
Clone No.: --
Immunogen: Purified recombinant human BACE (C-terminus) protein fragments expressed in E.coli.
Sequence: --
Specificity: BACE Monoclonal Antibody detects endogenous levels of BACE protein.
Gene Name: BACE1
Protein Name: Beta-secretase 1
Other Name: BACE1;BACE;KIAA1149;Beta-secretase 1;Aspartyl protease 2;ASP2;Asp 2;Beta-site amyloid precursor protein cleaving enzyme 1;Beta-site APP cleaving enzyme 1;Memapsin-2;Membrane-associated aspartic protease 2
Organism-1: Human
Gene ID-1: 23621
SwissProt-1: P56817
Organism-2: Mouse
Gene ID-2: --
SwissProt-2: P56818
Organism-3: Rat
Gene ID-3: 29392
SwissProt-3: P56819
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cell membrane ; Single-pass type I membrane protein . Golgi apparatus, trans-Golgi network . Endoplasmic reticulum . Endosome . Cell surface . Cytoplasmic vesicle membrane ; Single-pass type I membrane protein . Membrane raft . Lysosome . Late endosome . Early endosome . Recycling endosome . Cell projection, axon . Cell projection, dendrite . Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface (PubMed:17425515, PubMed:11466313). Colocalization with APP in early endosomes is due to addition of bisecting N-acetylglucosamine wich blocks targeting to late endosomes and lysosomes (By similarity). Retrogradly transported from endosomal compartments to the trans-Golgi network in a phosphorylation- and GGA1- dependent manner (PubMed:15886016). .