U-Blot® PP2B-Aα Monoclonal Antibody

Name: U-Blot® PP2B-Aα Monoclonal Antibody
SKU: WM0522
Availability: InStock

$268.00

Size:50μL

SKU: WM0522-50

Catalog No.: WM0522

Specification: 50μL/100μL

Stock: In stock

U-Blot® PP2B-Aα Monoclonal Antibody Learn more

Product details Specifications Q & A Education

Background：catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 1 Fe(3+) ion per subunit.,cofactor:Binds 1 zinc ion per subunit.,function:Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates HSPB1 and SSH1.,online information:Calcineurin entry,similarity:Belongs to the PPP phosphatase family.,similarity:Belongs to the PPP phosphatase family. PP-2B subfamily.,subcellular location:Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle.,subunit:Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with TORC2/CRTC2, MYOZ1, MYOZ2 and MYOZ3.,

Product Overview

Catalog No.: WM0522
SKU: WM0522-50
Category: Mouse mAbs
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: PP2B-Aα
Reactivity: Human,Mouse,Rat
Application: WB
MW(Calculated): 59kD
MW(Observed): --
Host Species: Mouse
Isotype: --
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:1000-1:2000;Not yet tested in other applications.
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: Affinity purification
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: --
Clonality: Monoclonal
Clone No.: --
Immunogen: Purified recombinant human PP2B-Aα protein fragments expressed in E.coli.
Sequence: --
Specificity: PP2B-Aα Monoclonal Antibody detects endogenous levels of PP2B-Aα protein.
Gene Name: PPP3CA
Protein Name: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Other Name: PP2B-Aα;PPP3CA;CALNA;CNA;Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform;CAM-PRP catalytic subunit;Calmodulin-dependent calcineurin A subunit alpha isoform
Organism-1: Human
Gene ID-1: 5530
SwissProt-1: Q08209
Organism-2: Mouse
Gene ID-2: 19055
SwissProt-2: P63328
Organism-3: Rat
Gene ID-3: 24674
SwissProt-3: P63329
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm . Cell membrane ; Peripheral membrane protein . Cell membrane, sarcolemma . Cytoplasm, myofibril, sarcomere, Z line . Cell projection, dendritic spine . Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle (By similarity). Recruited to the cell membrane by scaffold protein AKAP5 following L-type Ca(2+)-channel activation (PubMed:22343722). .