U-Blot® SMC1 Monoclonal Antibody

Name: U-Blot® SMC1 Monoclonal Antibody
SKU: WM0534
Availability: InStock

$268.00

Size:50μL

SKU: WM0534-50

Catalog No.: WM0534

Specification: 50μL/100μL

Stock: In stock

U-Blot® SMC1 Monoclonal Antibody Learn more

Product details Specifications Q & A Education

Background：structural maintenance of chromosomes 1A(SMC1A) Homo sapiens Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Altern

Product Overview

Catalog No.: WM0534
SKU: WM0534-50
Category: Mouse mAbs
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: SMC1
Reactivity: Human,Mouse,Rat,Pig
Application: WB,IHC,IF,Flow Cyt
MW(Calculated): 143kD
MW(Observed): --
Host Species: Mouse
Isotype: --
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:1000-1:2000;IHC 1:500-1:1000;Flow Cyt 1:100-1:200;IF 1:50-200
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: Affinity purification
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: --
Clonality: Monoclonal
Clone No.: --
Immunogen: Purified recombinant human SMC1 (N-terminus) protein fragments expressed in E.coli.
Sequence: --
Specificity: SMC1 Monoclonal Antibody detects endogenous levels of SMC1 protein.
Gene Name: SMC1A
Protein Name: Structural maintenance of chromosomes protein 1A
Other Name: SMC1A;DXS423E;KIAA0178;SB1.8;SMC1;SMC1L1;Structural maintenance of chromosomes protein 1A;SMC protein 1A;SMC-1-alpha;SMC-1A;Sb1.8
Organism-1: Human
Gene ID-1: 8243
SwissProt-1: Q14683
Organism-2: Mouse
Gene ID-2: 24061
SwissProt-2: Q9CU62
Organism-3: Rat
Gene ID-3: 63996
SwissProt-3: Q9Z1M9
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Nucleus . Chromosome . Chromosome, centromere, kinetochore . Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex. The phosphorylated form on Ser-957 and Ser-966 associates with chromatin during G1/S/G2 phases but not during M phase, suggesting that phosphorylation does not regulate cohesin function. Integral component of the functional centromere-kinetochore complex at the kinetochore region during mitosis.