U-Blot® SirT2 mouse mAb

Name: U-Blot® SirT2 mouse mAb
SKU: WM0602
Availability: InStock

$268.00

Size:50μL

SKU: WM0602-50

Catalog No.: WM0602

Specification: 50μL/100μL

Stock: In stock

U-Blot® SirT2 mouse mAb Learn more

Product details Specifications Q & A Education

Background：This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010],

Product Overview

Catalog No.: WM0602
SKU: WM0602-50
Category: Mouse mAbs
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: SirT2
Reactivity: Human,Mouse,Rat
Application: WB,IF
MW(Calculated): --
MW(Observed): 43kD
Host Species: Mouse
Isotype: --
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:1000;IF 1:50-200
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: --
Clonality: Monoclonal
Clone No.: --
Immunogen: Purified recombinant human SirT2 protein expressed in E.coli.
Sequence: --
Specificity: This antibody detects endogenous levels of SirT2 and does not cross-react with related proteins.
Gene Name: sirt2
Protein Name: NAD-dependent protein deacetylase sirtuin-2
Other Name: FLJ35621;FLJ37491;NAD dependent deacetylase sirtuin 2;NAD-dependent deacetylase sirtuin-2;NAD-dependent protein deacetylase sirtuin-2;Regulatory protein SIR2 homolog 2;Silencing information regulator 2 like;Silent information regulator 2;Silent mating type information regulation 2;Silent mating type information regulation 2 homolog;SIR 2;SIR2;SIR2 like;SIR2 like protein 2;Sir2 related protein type 2;SIR2, S. cerevisiae, homolog-loke 2;SIR2-like protein 2;SIR2L;SIR2L2;SIRT 2;SIRT2;SIRT2_HUMAN;Sirtuin;silent mating type information regulation 2 homolog;2;S.cerevisiae;Sirtuin 2;Sirtuin type 2;Sirtuin2.
Organism-1: Human
Gene ID-1: 22933
SwissProt-1: Q8IXJ6
Organism-2: Mouse
Gene ID-2: --
SwissProt-2: Q8VDQ8
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Nucleus . Cytoplasm, perinuclear region . Cytoplasm . Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, spindle . Midbody . Chromosome . Perikaryon . Cell projection . Cell projection, growth cone . Myelin membrane . Localizes in the cytoplasm during most of the cell cycle except in the G2/M transition and during mitosis, where it is localized in association with chromatin and induces deacetylation of histone at 'Lys-16' (H4K16ac) (PubMed:17726514, PubMed:23468428). Colocalizes with KMT5A at mitotic foci (PubMed:23468428). Colocalizes with CDK1 at centrosome during prophase and splindle fibers during metaphase (PubMed:17488717). Colocalizes with Aurora kinase AURKA at centrosome during early prophase and in the centrioles and growing mitotic spindle throughout metaphase (PubMed:17488717). Colocalizes with Aurora kinase AURKB during cytokinesis with the midbody (PubMed:17488717). Colocalizes with microtubules (PubMed:12620231). Detected in perinuclear foci that may be aggresomes containing misfolded, ubiquitinated proteins (By similarity). Shuttles between the cytoplasm and the nucleus through the CRM1 export pathway (PubMed:17726514). Colocalizes with EP300 in the nucleus (PubMed:24177535). Translocates to the nucleus and chromatin upon bacterium Listeria monocytogenes infection in interphase cells (PubMed:23908241). Deacetylates FOXO3 in the cytoplasm (By similarity). Colocalizes with PLP1 in internodal regions, at paranodal axoglial junction and Schmidt-Lanterman incisures of myelin sheat (By similarity). Colocalizes with CDK5R1 in the perikaryon, neurites and growth cone of hippocampal neurons (By similarity). Colocalizes with alpha-tubulin in neuronal growth cone (By similarity). Localizes in the cytoplasm and nucleus of germinal vesicle (GV) stage oocytes (By similarity). Colocalizes with alpha-tubulin on the meiotic spindle as the oocytes enter into metaphase, and also during meiotic anaphase and telophase, especially with the midbody (By similarity). Colocalizes with PARD3 in internodal region of axons (By similarity). Colocalizes with acetylated alpha-tubulin in cell projection processes during primary oligodendrocyte precursor (OLP) differentiation (By similarity). .; [Isoform 1]: Cytoplasm . Nucleus . Predominantly localized in the cytoplasmic. .; [Isoform 2]: Cytoplasm . Nucleus . Predominantly localized in the cytoplasmic. .; [Isoform 5]: Cytoplasm . Nucleus . Predominantly localized in the nucleus. .