U-Blot® FOXO1(C-term) mouse mAb

Name: U-Blot® FOXO1(C-term) mouse mAb
SKU: WM0607
Availability: InStock

$268.00

Size:50μL

SKU: WM0607-50

Catalog No.: WM0607

Specification: 50μL/100μL

Stock: In stock

U-Blot® FOXO1(C-term) mouse mAb Learn more

Product details Specifications Q & A Education

Background：This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008],

Product Overview

Catalog No.: WM0607
SKU: WM0607-50
Category: Mouse mAbs
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: FoxO1
Reactivity: Human
Application: WB
MW(Calculated): --
MW(Observed): 70kD
Host Species: Mouse
Isotype: --
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:1000
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: --
Clonality: Monoclonal
Clone No.: --
Immunogen: Purified recombinant human FOXO1(C-terminus) protein fragments expressed in E.coli.
Sequence: --
Specificity: This antibody detects endogenous levels of FOXO1(C-terminus) and does not cross-react with related proteins.
Gene Name: foxo1
Protein Name: --
Other Name: FKH 1;FKH1;FKH1;FKHR;FKHR;Forkhead;Drosophila;homolog 1;rhabdomyosarcoma;Forkhead;Drosophila;homolog 1;rhabdomyosarcoma;Forkhead box O1;Forkhead box protein O1;Forkhead box protein O1A;Forkhead in rhabdomyosarcoma;Forkhead, Drosophila, homolog of, in rhabdomyosarcoma;FOXO1;FOXO1;FOXO1_HUMAN;FOXO1A;OTTHUMP00000018301.
Organism-1: Human
Gene ID-1: 2308
SwissProt-1: Q12778
Organism-2: Mouse
Gene ID-2: --
SwissProt-2: Q9R1E0
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm . Nucleus . Shuttles between the cytoplasm and nucleus. Largely nuclear in unstimulated cells (PubMed:11311120, PubMed:12228231, PubMed:19221179, PubMed:21245099, PubMed:20543840, PubMed:25009184). In osteoblasts, colocalizes with ATF4 and RUNX2 in the nucleus (By similarity). Serum deprivation increases localization to the nucleus, leading to activate expression of SOX9 and subsequent chondrogenesis (By similarity). Insulin-induced phosphorylation at Ser-256 by PKB/AKT1 leads, via stimulation of Thr-24 phosphorylation, to binding of 14-3-3 proteins and nuclear export to the cytoplasm where it is degraded by the ubiquitin-proteosomal pathway (PubMed:11237865, PubMed:12228231). Phosphorylation at Ser-249 by CDK1 disrupts binding of 14-3-3 proteins and promotes nuclear accumulation (PubMed:18356527). Phosphorylation by NLK results in nuclear export (By similarity). Translocates to the nucleus upon oxidative stress-induced phosphorylation at Ser-212 by STK4/MST1 (PubMed:19221179, PubMed:21245099). SGK1-mediated phosphorylation also results in nuclear translocation (By similarity). Retained in the nucleus under stress stimuli including oxidative stress, nutrient deprivation or nitric oxide (By similarity). Retained in the nucleus on methylation (By similarity). PPIA/CYPA stimulates its nuclear accumulation (PubMed:31063815). Deacetylation by SIRT6, promotes its translocation into the cytoplasm (PubMed:25009184). .