U-Blot® CDC2/CDK1 mouse mAb

Name: U-Blot® CDC2/CDK1 mouse mAb
SKU: WM0620
Availability: InStock

$268.00

Size:50μL

SKU: WM0620-50

Catalog No.: WM0620

Specification: 50μL/100μL

Stock: In stock

U-Blot® CDC2/CDK1 mouse mAb Learn more

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Background：cyclin dependent kinase 1(CDK1) Homo sapiens The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009],

Product Overview

Catalog No.: WM0620
SKU: WM0620-50
Category: Mouse mAbs
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: CDK1/CDC2
Reactivity: Human
Application: WB,ICC
MW(Calculated): --
MW(Observed): 34kD
Host Species: Mouse
Isotype: --
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:100;ICC 1:50
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: --
Clonality: Monoclonal
Clone No.: --
Immunogen: Purified recombinant human CDC2/CDK1 protein fragments expressed in E.coli.
Sequence: --
Specificity: This antibody detects endogenous levels of CDC2/CDK1 and does not cross-react with related proteins.
Gene Name: cdk1
Protein Name: --
Other Name: Cdc 2;Cdc2;CDC28A;CDK 1;CDK1;CDK1_HUMAN;CDKN1;CELL CYCLE CONTROLLER CDC2;Cell division control protein 2;Cell division control protein 2 homolog;Cell division cycle 2 G1 to S and G2 to M;Cell division protein kinase 1;Cell Divsion Cycle 2 Protein;Cyclin Dependent Kinase 1;Cyclin-dependent kinase 1;DKFZp686L20222;MGC111195;p34 Cdk1;p34 protein kinase;P34CDC2.
Organism-1: Human
Gene ID-1: 983
SwissProt-1: P06493
Organism-2: Mouse
Gene ID-2: --
SwissProt-2: P11440
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Nucleus. Cytoplasm. Mitochondrion . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle. Cytoplasmic during the interphase. Colocalizes with SIRT2 on centrosome during prophase and on splindle fibers during metaphase of the mitotic cell cycle. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when associated with cyclin-B1. Accumulates in mitochondria in G2-arrested cells upon DNA-damage.