- Target
- SphK2
- Reactivity
- Human,Mouse,Rat
- Application
- WB,IHC
- MW(Calculated)
- 72kD
- MW(Observed)
- --
- Host Species
- Mouse
- Isotype
- --
- Conjugate/Modification
- Unmodified
- Modification site
- --
- Recommended Dilution Ratio
- WB 1:500-2000;IHC 1:50-200
- Form
- Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
- Source
- --
- Purification
- The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
- Purity
- --
- storageCondition
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Concentration
- 1 mg/ml
- Clonality
- Monoclonal
- Clone No.
- 7A5
- Immunogen
- Synthesized peptide derived from human SPHK2
- Sequence
- --
- Specificity
- This antibody detects endogenous levels of SPHK2 at Human, Mouse,Rat
- Gene Name
- SPHK2
- Protein Name
- SPHK2
- Other Name
- Sphingosine kinase 2;SK 2;SPK 2;
- Organism-1
- Human
- Gene ID-1
- 56848
- SwissProt-1
- Q9NRA0
- Organism-2
- Mouse
- Gene ID-2
- 56632
- SwissProt-2
- Q9JIA7
- Organism-3
- --
- Gene ID-3
- --
- SwissProt-3
- --
- Organism-4
- --
- gene ID-4
- --
- SwissProt-4
- --
- Cellular Localization
- Cytoplasm . Nucleus . Endoplasmic reticulum . Mitochondrion inner membrane . In nucleus, located in nucleosomes where it associates with core histone proteins such as histone 3 (PubMed:19729656). In brains of patients with Alzheimer's disease, may be preferentially localized in the nucleus. Cytosolic expression decrease correlates with the density of amyloid deposits (PubMed:29615132). In apoptotic cells, colocalizes with CASP1 in cell membrane where is cleaved and released from cells in an active form (PubMed:20197547). .; [Isoform 2]: Lysosome membrane .