U-Blot® BMAL1 (Acetyl Lys538) Polyclonal Antibody

Name: U-Blot® BMAL1 (Acetyl Lys538) Polyclonal Antibody
SKU: WP0288
Availability: InStock

$288.00

Size:50μL

SKU: WP0288-50

Catalog No.: WP0288

Specification: 50μL/100μL

Stock: In stock

U-Blot® BMAL1 (Acetyl Lys538) Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014],

Product Overview

Catalog No.: WP0288
SKU: WP0288-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: BMAL1
Reactivity: Human,Mouse,Rat
Application: WB,ELISA
MW(Calculated): --
MW(Observed): 70kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Acetyl
Modification site: --
Recommended Dilution Ratio: WB 1:500-1:2000;ELISA 1:20000;Not yet tested in other applications.
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized Acetyl-peptide derived from human BMAL1 around the Acetylation site of Lys538. AA range:501-550
Sequence: --
Specificity: Acetyl-BMAL1 (K538) Polyclonal Antibody detects endogenous levels of BMAL1 protein only when acetylated at K538.
Gene Name: ARNTL
Protein Name: Aryl hydrocarbon receptor nuclear translocator-like protein 1
Other Name: ARNTL;BHLHE5;BMAL1;MOP3;PASD3;Aryl hydrocarbon receptor nuclear translocator-like protein 1;Basic-helix-loop-helix-PAS protein MOP3Brain and muscle ARNT-like 1;Class E basic helix-loop-helix protein 5;bHLHe5;Member of PAS protein 3;PAS domain-containing protein 3;bHLH-PAS protein JAP3
Organism-1: Human
Gene ID-1: 406
SwissProt-1: O00327
Organism-2: Mouse
Gene ID-2: 11865
SwissProt-2: Q9WTL8
Organism-3: Rat
Gene ID-3: 29657
SwissProt-3: Q9EPW1
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Nucleus . Cytoplasm . Nucleus, PML body . Shuttles between the nucleus and the cytoplasm and this nucleocytoplasmic shuttling is essential for the nuclear accumulation of CLOCK, target gene transcription and the degradation of the CLOCK-ARNTL/BMAL1 heterodimer. The sumoylated form localizes in the PML body. Sequestered to the cytoplasm in the presence of ID2. .