U-Blot® HMG-1 (Acetyl Lys3) rabbit pAb

Name: U-Blot® HMG-1 (Acetyl Lys3) rabbit pAb
SKU: WP0391
Availability: InStock

$288.00

Size:50μL

SKU: WP0391-50

Catalog No.: WP0391

Specification: 50μL/100μL

Stock: In stock

U-Blot® HMG-1 (Acetyl Lys3) rabbit pAb Learn more

Product details Specifications Q & A Education

Background：function:Binds preferentially single-stranded DNA and unwinds double stranded DNA.,similarity:Belongs to the HMGB family.,similarity:Contains 2 HMG box DNA-binding domains.,

Product Overview

Catalog No.: WP0391
SKU: WP0391-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: HMGB1
Reactivity: Human,Mouse,Rat
Application: WB,ELISA
MW(Calculated): --
MW(Observed): 30kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Acetyl
Modification site: --
Recommended Dilution Ratio: WB 1:1000-2000;ELISA 1:5000-20000
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized peptide derived from human HMG-1 (Acetyl Lys3)
Sequence: --
Specificity: This antibody detects endogenous levels of Human,Mouse,Rat HMG-1 (Acetyl Lys3)
Gene Name: HMGB1 HMG1
Protein Name: HMG-1 (Acetyl Lys3)
Other Name: High mobility group protein B1;High mobility group protein 1;HMG-1;
Organism-1: Human
Gene ID-1: 3146
SwissProt-1: P09429
Organism-2: Mouse
Gene ID-2: 100862258
SwissProt-2: P63158
Organism-3: Rat
Gene ID-3: 25459
SwissProt-3: P63159
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Nucleus . Chromosome . Cytoplasm . Secreted . Cell membrane ; Peripheral membrane protein ; Extracellular side . Endosome . Endoplasmic reticulum-Golgi intermediate compartment . In basal state predominantly nuclear. Shuttles between the cytoplasm and the nucleus (PubMed:12231511, PubMed:17114460). Translocates from the nucleus to the cytoplasm upon autophagy stimulation (PubMed:20819940). Release from macrophages in the extracellular milieu requires the activation of NLRC4 or NLRP3 inflammasomes (By similarity). Passively released to the extracellular milieu from necrotic cells by diffusion, involving the fully reduced HGMB1 which subsequently gets oxidized (PubMed:19811284). Also released from apoptotic cells (PubMed:16855214, PubMed:18631454). Active secretion from a variety of immune and non-immune cells such as macrophages, monocytes, neutrophils, dendritic cells and natural killer cells in response to various stimuli such as LPS and cytokines involves a nonconventional secretory process via secretory lysosomes (PubMed:12231511, PubMed:14532127, PubMed:15944249). Secreted by plasma cells in response to LPS (By similarity). Found on the surface of activated platelets (PubMed:11154118). An increased chromatin association is observed when associated with the adenovirus protein pVII (PubMed:27362237). .