U-Blot® Smad7 (Acetyl Lys70) rabbit pAb

Name: U-Blot® Smad7 (Acetyl Lys70) rabbit pAb
SKU: WP0415
Availability: InStock

$288.00

Size:50μL

SKU: WP0415-50

Catalog No.: WP0415

Specification: 50μL/100μL

Stock: In stock

U-Blot® Smad7 (Acetyl Lys70) rabbit pAb Learn more

Product details Specifications Q & A Education

Background：The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010],

Product Overview

Catalog No.: WP0415
SKU: WP0415-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: Smad7
Reactivity: Human,Mouse,Rat
Application: WB,IHC
MW(Calculated): 47kD
MW(Observed): --
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Acetyl
Modification site: --
Recommended Dilution Ratio: WB 1:500-2000;IHC 1:50-300
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized peptide derived from human Smad7 (Acetyl Lys70)
Sequence: --
Specificity: This antibody detects endogenous levels of Human,Mouse,Rat Smad7 (Acetyl Lys70)
Gene Name: SMAD7 MADH7 MADH8
Protein Name: Smad7 (Acetyl Lys70)
Other Name: Mothers against decapentaplegic homolog 7;MAD homolog 7;Mothers against DPP homolog 7;Mothers against decapentaplegic homolog 8;MAD homolog 8;Mothers against DPP homolog 8;SMAD family member 7;SMAD 7;Smad7;hSMAD7;
Organism-1: Human
Gene ID-1: 4092
SwissProt-1: O15105
Organism-2: Mouse
Gene ID-2: 17131
SwissProt-2: O35253
Organism-3: Rat
Gene ID-3: 81516
SwissProt-3: O88406
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Nucleus . Cytoplasm . Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm (PubMed:16601693). TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus to the cytoplasm in response to TGF-beta (PubMed:17327236). .