U-Blot® APBB1 Polyclonal Antibody

Name: U-Blot® APBB1 Polyclonal Antibody
SKU: WP0865
Availability: InStock

$268.00

Size:50μL

SKU: WP0865-50

Catalog No.: WP0865

Specification: 50μL/100μL

Stock: In stock

U-Blot® APBB1 Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：amyloid beta precursor protein binding family B member 1(APBB1) Homo sapiens The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Mar 2012],

Product Overview

Catalog No.: WP0865
SKU: WP0865-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: APBB1
Reactivity: Human,Mouse,Rat
Application: WB,ELISA
MW(Calculated): --
MW(Observed): 78kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:500-2000;ELISA 1:5000-20000
Form: PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized peptide derived from human protein . at AA range: 400-480
Sequence: --
Specificity: APBB1 Polyclonal Antibody detects endogenous levels of protein.
Gene Name: APBB1 FE65 RIR
Protein Name: Amyloid beta A4 precursor protein-binding family B member 1 (Protein Fe65)
Other Name: --
Organism-1: Human
Gene ID-1: 322
SwissProt-1: O00213
Organism-2: Mouse
Gene ID-2: --
SwissProt-2: Q9QXJ1
Organism-3: Rat
Gene ID-3: --
SwissProt-3: P46933
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cell membrane . Cytoplasm . Nucleus . Cell projection, growth cone . Nucleus speckle . Colocalizes with TSHZ3 in axonal growth cone (By similarity). Colocalizes with TSHZ3 in the nucleus (PubMed:19343227). In normal conditions, it mainly localizes to the cytoplasm, while a small fraction is tethered to the cell membrane via its interaction with APP (PubMed:18468999). Following exposure to DNA damaging agents, it is released from cell membrane and translocates to the nucleus (PubMed:18468999). Nuclear translocation is under the regulation of APP (PubMed:18468999). Colocalizes with NEK6 at the nuclear speckles (PubMed:17512906). Phosphorylation at Ser-610 by SGK1 promotes its localization to the nucleus (By similarity). .