U-Blot® Flk-1/Flt-4 (phospho Tyr1054/Y1063) Polyclonal Antibody

Name: U-Blot® Flk-1/Flt-4 (phospho Tyr1054/Y1063) Polyclonal Antibody
SKU: WP10026
Availability: InStock

$288.00

Size:50μL

SKU: WP10026-50

Catalog No.: WP10026

Specification: 50μL/100μL

Stock: In stock

U-Blot® Flk-1/Flt-4 (phospho Tyr1054/Y1063) Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009],

Product Overview

Catalog No.: WP10026
SKU: WP10026-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: VEGFR2/VEGFR3
Reactivity: Human,Mouse,Rat
Application: IHC,IF,ELISA
MW(Calculated): 152kD
MW(Observed): --
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: IHC 1:100-1:300;ELISA 1:40000;IF 1:50-200
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human VEGFR2 around the phosphorylation site of Tyr1054. AA range:1020-1069
Sequence: --
Specificity: Phospho-Flk-1/Flt-4 (Y1054/Y1063) Polyclonal Antibody detects endogenous levels of Flk-1/Flt-4 protein only when phosphorylated at Y1054/Y1063.
Gene Name: KDR/FLT4
Protein Name: Vascular endothelial growth factor receptor 2/3
Other Name: KDR;FLK1;VEGFR2;Vascular endothelial growth factor receptor 2;VEGFR-2;Fetal liver kinase 1;FLK-1;Kinase insert domain receptor;KDR;Protein-tyrosine kinase receptor flk-1;CD antigen CD309;FLT4;VEGFR3;Vascular endothelial growth
Organism-1: Human
Gene ID-1: 3791;2324
SwissProt-1: P35968;P35916
Organism-2: Mouse
Gene ID-2: 14257
SwissProt-2: --
Organism-3: Rat
Gene ID-3: 25589;114110
SwissProt-3: O08775;Q91ZT1
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cell junction . Endoplasmic reticulum . Cell membrane . Localized with RAP1A at cell-cell junctions (By similarity). Colocalizes with ERN1 and XBP1 in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF)-dependent manner (PubMed:23529610). .; [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cytoplasm. Nucleus. Cytoplasmic vesicle. Early endosome. Detected on caveolae-enriched lipid rafts at the cell surface. Is recycled from the plasma membrane to endosomes and back again. Phosphorylation triggered by VEGFA binding promotes internalization and subsequent degradation. VEGFA binding triggers internalization and translocation to the nucleus.; [Isoform 2]: Secreted .; [Isoform 3]: Secreted.