U-Blot® ARK-2/3 (phospho Thr236/202) Polyclonal Antibody

Name: U-Blot® ARK-2/3 (phospho Thr236/202) Polyclonal Antibody
SKU: WP10044
Availability: InStock

$288.00

Size:50μL

SKU: WP10044-50

Catalog No.: WP10044

Specification: 50μL/100μL

Stock: In stock

U-Blot® ARK-2/3 (phospho Thr236/202) Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015],

Product Overview

Catalog No.: WP10044
SKU: WP10044-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: AurB/C
Reactivity: Human,Mouse,Rat
Application: IHC,IF,ELISA
MW(Calculated): 35-40kD
MW(Observed): --
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: IHC 1:100-1:300;ELISA 1:10000;IF 1:50-200
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human AurB/C around the phosphorylation site of Thr236/202. AA range:201-250
Sequence: --
Specificity: Phospho-ARK-2/3 (T236/202) Polyclonal Antibody detects endogenous levels of ARK-2/3 protein only when phosphorylated at T236/202.
Gene Name: AURKB/AURKC
Protein Name: Serine/threonine-protein kinase 12/Aurora kinase C
Other Name: AURKB;AIK2;AIM1;AIRK2;ARK2;STK1;STK12;STK5;Aurora kinase B;Aurora 1;Aurora- and IPL1-like midbody-associated protein 1;AIM-1;Aurora/IPL1-related kinase 2;ARK-2;Aurora-related kinase 2;STK-1;Serine/threonine-protein kinase 12
Organism-1: Human
Gene ID-1: 9212;6795
SwissProt-1: Q96GD4;Q9UQB9
Organism-2: Mouse
Gene ID-2: 20877
SwissProt-2: --
Organism-3: Rat
Gene ID-3: 114592
SwissProt-3: O55099
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Nucleus . Chromosome . Chromosome, centromere . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle . Midbody . Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis (PubMed:20929775). Colocalized with gamma tubulin in the midbody (PubMed:17726514). Proper localization of the active, Thr-232-phosphorylated form during metaphase may be dependent upon interaction with SPDYC (PubMed:20605920). Colocalized with SIRT2 during cytokinesis with the midbody (PubMed:17726514). Localization (and probably targeting of the CPC) to the inner centromere occurs predominantly in regions with overlapping mitosis-specific histone phosphorylations H3pT3 and H2ApT12 (PubMed:20929775). .