U-Blot® MDC1 (phospho Ser513) Polyclonal Antibody

Name: U-Blot® MDC1 (phospho Ser513) Polyclonal Antibody
SKU: WP10129
Availability: InStock

$288.00

Size:50μL

SKU: WP10129-50

Catalog No.: WP10129

Specification: 50μL/100μL

Stock: In stock

U-Blot® MDC1 (phospho Ser513) Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008],

Product Overview

Catalog No.: WP10129
SKU: WP10129-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: MDC1
Reactivity: Human,Rat,Mouse,
Application: IHC,IF,ELISA
MW(Calculated): 227kD
MW(Observed): --
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: IHC 1:100-1:300;ELISA 1:5000;IF 1:50-200
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human MDC1 around the phosphorylation site of Ser513. AA range:479-528
Sequence: --
Specificity: Phospho-MDC1 (S513) Polyclonal Antibody detects endogenous levels of MDC1 protein only when phosphorylated at S513.
Gene Name: MDC1
Protein Name: Mediator of DNA damage checkpoint protein 1
Other Name: MDC1;KIAA0170;NFBD1;Mediator of DNA damage checkpoint protein 1;Nuclear factor with BRCT domains 1
Organism-1: Human
Gene ID-1: 9656
SwissProt-1: Q14676
Organism-2: Mouse
Gene ID-2: --
SwissProt-2: Q5PSV9
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Nucleus . Chromosome . Associated with chromatin. Relocalizes to discrete nuclear foci following DNA damage, this requires 'Ser-139' phosphorylation of H2AX. Colocalizes with APTX at sites of DNA double-strand breaks.