U-Blot® NFATc4 (phospho Ser168/S170) Polyclonal Antibody

Name: U-Blot® NFATc4 (phospho Ser168/S170) Polyclonal Antibody
SKU: WP10133
Availability: InStock

$288.00

Size:50μL

SKU: WP10133-50

Catalog No.: WP10133

Specification: 50μL/100μL

Stock: In stock

U-Blot® NFATc4 (phospho Ser168/S170) Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014],

Product Overview

Catalog No.: WP10133
SKU: WP10133-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: NFAT3
Reactivity: Human,Mouse
Application: WB,IHC,IF,ELISA
MW(Calculated): --
MW(Observed): 140kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:5000;IF 1:50-200
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human NFAT3 around the phosphorylation site of Ser168 and Ser170. AA range:136-185
Sequence: --
Specificity: Phospho-NFATc4 (S168/S170) Polyclonal Antibody detects endogenous levels of NFATc4 protein only when phosphorylated at S168/S170.
Gene Name: NFATC4
Protein Name: Nuclear factor of activated T-cells cytoplasmic 4
Other Name: NFATC4;NFAT3;Nuclear factor of activated T-cells;cytoplasmic 4;NF-ATc4;NFATc4;T-cell transcription factor NFAT3;NF-AT3
Organism-1: Human
Gene ID-1: 4776
SwissProt-1: Q14934
Organism-2: Mouse
Gene ID-2: 73181
SwissProt-2: Q8K120
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm, cytosol . Nucleus . When hyperphosphorylated, localizes in the cytosol. When intracellular Ca(2+) levels increase, dephosphorylation by calcineurin/PPP3CA leads to translocation into the nucleus (PubMed:11997522, PubMed:18347059). MAPK7/ERK5 and MTOR regulate NFATC4 nuclear export through phosphorylation at Ser-168 and Ser-170 (PubMed:18347059). .