U-Blot® Synuclein-α (phospho Tyr125) Polyclonal Antibody

Name: U-Blot® Synuclein-α (phospho Tyr125) Polyclonal Antibody
SKU: WP10153
Availability: InStock

$288.00

Size:50μL

SKU: WP10153-50

Catalog No.: WP10153

Specification: 50μL/100μL

Stock: In stock

U-Blot® Synuclein-α (phospho Tyr125) Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016],

Product Overview

Catalog No.: WP10153
SKU: WP10153-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: Synuclein-α
Reactivity: Human,Mouse,Rat
Application: WB,IHC,IF,ELISA
MW(Calculated): 14kD
MW(Observed): --
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: WB 1:500-2000;IHC 1:100-1:300;ELISA 1:20000;IF 1:50-200
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human Synuclein-alpha around the phosphorylation site of Tyr125. AA range:91-140
Sequence: --
Specificity: Phospho-Synuclein-α (Y125) Polyclonal Antibody detects endogenous levels of Synuclein-α protein only when phosphorylated at Y125.
Gene Name: SNCA
Protein Name: Alpha-synuclein
Other Name: SNCA;NACP;PARK1;Alpha-synuclein;Non-A beta component of AD amyloid;Non-A4 component of amyloid precursor;NACP
Organism-1: Human
Gene ID-1: 6622
SwissProt-1: P37840
Organism-2: Mouse
Gene ID-2: 20617
SwissProt-2: O55042
Organism-3: Rat
Gene ID-3: 29219
SwissProt-3: P37377
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm . Membrane . Nucleus . Cell junction, synapse . Secreted . Cell projection, axon . Membrane-bound in dopaminergic neurons (PubMed:15282274). Expressed and colocalized with SEPTIN4 in dopaminergic axon terminals, especially at the varicosities (By similarity). .