U-Blot® Kv2.1 (phospho Ser567) Polyclonal Antibody

Name: U-Blot® Kv2.1 (phospho Ser567) Polyclonal Antibody
SKU: WP10185
Availability: InStock

$288.00

Size:50μL

SKU: WP10185-50

Catalog No.: WP10185

Specification: 50μL/100μL

Stock: In stock

U-Blot® Kv2.1 (phospho Ser567) Polyclonal Antibody Learn more

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Background：Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008],

Product Overview

Catalog No.: WP10185
SKU: WP10185-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: Kv2.1
Reactivity: Human,Mouse,Rat
Application: IHC,IF,ELISA
MW(Calculated): 96kD
MW(Observed): --
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: IHC 1:100-1:300;IF 1:200-1:1000;ELISA 1:10000;Not yet tested in other applications.
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human Kv2.1/KCNB1 around the phosphorylation site of Ser567. AA range:533-582
Sequence: --
Specificity: Phospho-Kv2.1 (S567) Polyclonal Antibody detects endogenous levels of Kv2.1 protein only when phosphorylated at S567.
Gene Name: KCNB1
Protein Name: Potassium voltage-gated channel subfamily B member 1
Other Name: KCNB1;Potassium voltage-gated channel subfamily B member 1;Delayed rectifier potassium channel 1;DRK1;h-DRK1;Voltage-gated potassium channel subunit Kv2.1
Organism-1: Human
Gene ID-1: 3745
SwissProt-1: Q14721
Organism-2: Mouse
Gene ID-2: 16500
SwissProt-2: Q03717
Organism-3: Rat
Gene ID-3: 25736
SwissProt-3: P15387
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cell membrane . Perikaryon . Cell projection, axon . Cell projection, dendrite . Membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane . Cell junction, synapse . Cell junction, synapse, synaptosome . Lateral cell membrane . Cell membrane, sarcolemma . Localizes to high-density somatodendritic clusters and non-clustered sites on the surface of neocortical and hippocampal pyramidal neurons in a cortical actin cytoskeleton-dependent manner (PubMed:24477962). Localizes also to high-density clusters in the axon initial segment (AIS), at ankyrin-G-deficient sites, on the surface of neocortical and hippocampal pyramidal neurons (PubMed:24477962). KCNB1-containing AIS clusters localize either in close apposition to smooth endoplasmic reticulum cisternal organelles or with GABA-A receptor-containing synapses of hippocampal and cortical pyramidal neurons, respectively (PubMed:24477962). Localizes to high-density clusters on the cell surface of atrial and ventricular myocytes and at the lateral plasma membrane in epithelial cells. Localizes both to the axial and transverse tubules (T tubule) and sarcolemma in ventricular myocytes. Associated with lipid raft domains. In cortical neurons, apoptotic injuries induce de novo plasma membrane insertion in a SNARE-dependent manner causing an apoptotic potassium current surge. .