U-Blot® Trk A (phospho Tyr496) Polyclonal Antibody

Name: U-Blot® Trk A (phospho Tyr496) Polyclonal Antibody
SKU: WP10194
Availability: InStock

$288.00

Size:50μL

SKU: WP10194-50

Catalog No.: WP10194

Specification: 50μL/100μL

Stock: In stock

U-Blot® Trk A (phospho Tyr496) Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008],

Product Overview

Catalog No.: WP10194
SKU: WP10194-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: Trk A
Reactivity: Human,Mouse,Rat
Application: WB,IF,ELISA
MW(Calculated): --
MW(Observed): 140-180kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: WB 1:500-2000;IF 1:200-1:1000;ELISA 1:5000;Not yet tested in other applications.
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human Trk A around the phosphorylation site of Tyr496. AA range:471-520
Sequence: --
Specificity: Phospho-Trk A (Y496) Polyclonal Antibody detects endogenous levels of Trk A protein only when phosphorylated at Y496.
Gene Name: NTRK1
Protein Name: High affinity nerve growth factor receptor
Other Name: NTRK1;MTC;TRK;TRKA;High affinity nerve growth factor receptor;Neurotrophic tyrosine kinase receptor type 1;TRK1-transforming tyrosine kinase protein;Tropomyosin-related kinase A;Tyrosine kinase receptor;Tyrosine kinase receptor A;
Organism-1: Human
Gene ID-1: 4914
SwissProt-1: P04629
Organism-2: Mouse
Gene ID-2: 18211
SwissProt-2: Q3UFB7
Organism-3: Rat
Gene ID-3: 59109
SwissProt-3: P35739
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cell membrane ; Single-pass type I membrane protein . Early endosome membrane ; Single-pass type I membrane protein . Late endosome membrane ; Single-pass type I membrane protein . Recycling endosome membrane ; Single-pass type I membrane protein . Rapidly internalized after NGF binding (PubMed:1281417). Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport. Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPGEF2 at late endosomes. .