U-Blot® Rb (phospho Ser249) Polyclonal Antibody

Name: U-Blot® Rb (phospho Ser249) Polyclonal Antibody
SKU: WP10213
Availability: InStock

$288.00

Size:50μL

SKU: WP10213-50

Catalog No.: WP10213

Specification: 50μL/100μL

Stock: In stock

U-Blot® Rb (phospho Ser249) Polyclonal Antibody Learn more

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Background：The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008],

Product Overview

Catalog No.: WP10213
SKU: WP10213-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: Rb
Reactivity: Human,Mouse,Rat
Application: WB,ELISA,IHC
MW(Calculated): 106kD
MW(Observed): --
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: WB 1:500-2000;IHC 1:50-300;ELISA 1:2000-20000
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human Retinoblastoma around the phosphorylation site of Ser249. AA range:221-270
Sequence: --
Specificity: Phospho-Rb (S249) Polyclonal Antibody detects endogenous levels of Rb protein only when phosphorylated at S249.
Gene Name: RB1
Protein Name: Retinoblastoma-associated protein
Other Name: RB1;Retinoblastoma-associated protein;p105-Rb;pRb;Rb;pp110
Organism-1: Human
Gene ID-1: 5925
SwissProt-1: P06400
Organism-2: Mouse
Gene ID-2: 19645
SwissProt-2: P13405
Organism-3: Rat
Gene ID-3: 24708
SwissProt-3: P33568
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Nucleus . During keratinocyte differentiation, acetylation by KAT2B/PCAF is required for nuclear localization. .