U-Blot® PKD2 (phospho Ser812) Polyclonal Antibody

Name: U-Blot® PKD2 (phospho Ser812) Polyclonal Antibody
SKU: WP10225
Availability: InStock

$288.00

Size:50μL

SKU: WP10225-50

Catalog No.: WP10225

Specification: 50μL/100μL

Stock: In stock

U-Blot® PKD2 (phospho Ser812) Polyclonal Antibody Learn more

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Background：polycystin 2, transient receptor potential cation channel(PKD2) Homo sapiens This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2. [provided by RefSeq, Mar 2011],

Product Overview

Catalog No.: WP10225
SKU: WP10225-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: PKD2
Reactivity: Human,Mouse,Rat
Application: WB,ELISA,IHC
MW(Calculated): 97kD
MW(Observed): --
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: WB 1:500-2000;IHC 1:50-300;ELISA 1:2000-20000
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human PKD2 around the phosphorylation site of Ser812. AA range:778-827
Sequence: --
Specificity: Phospho-PKD2 (S812) Polyclonal Antibody detects endogenous levels of PKD2S812.
Gene Name: PKD2
Protein Name: Polycystin-2
Other Name: PKD2;Polycystin-2;Autosomal dominant polycystic kidney disease type II protein;Polycystic kidney disease 2 protein;Polycystwin;R48321
Organism-1: Human
Gene ID-1: 5311
SwissProt-1: Q13563
Organism-2: Mouse
Gene ID-2: 18764
SwissProt-2: O35245
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cell projection, cilium membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Basolateral cell membrane . Cytoplasmic vesicle membrane . Golgi apparatus . PKD2 localization to the plasma and ciliary membranes requires PKD1. PKD1:PKD2 interaction is required to reach the Golgi apparatus form endoplasmic reticulum and then traffic to the cilia (By similarity). Retained in the endoplasmic reticulum by interaction with PACS1 and PACS2 (PubMed:15692563). Detected on kidney tubule basolateral membranes and basal cytoplasmic vesicles (PubMed:10770959). Cell surface and cilium localization requires GANAB (PubMed:27259053). .