U-Blot® ERK 1/2 (phospho Thr202/Y204) Polyclonal Antibody

Name: U-Blot® ERK 1/2 (phospho Thr202/Y204) Polyclonal Antibody
SKU: WP10226
Availability: InStock

$288.00

Size:50μL

SKU: WP10226-50

Catalog No.: WP10226

Specification: 50μL/100μL

Stock: In stock

U-Blot® ERK 1/2 (phospho Thr202/Y204) Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008],

Product Overview

Catalog No.: WP10226
SKU: WP10226-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: ERK 1/2
Reactivity: Human,Mouse,Rat,Fish
Application: IF,WB,IHC,ELISA
MW(Calculated): 43kD
MW(Observed): --
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: IF 1:50-200;WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:20000;Not yet tested in other applications;
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized phospho-peptide around the phosphorylation site of human ERK 1/2 (phospho Thr202/Y204)
Sequence: --
Specificity: Phospho-ERK 1/2 (T202/Y204) Polyclonal Antibody detects endogenous levels of ERK 1/2 protein only when phosphorylated at T202 or Y204.
Gene Name: MAPK1/MAPK3
Protein Name: Mitogen-activated protein kinase 3
Other Name: MAPK3;ERK1;PRKM3;Mitogen-activated protein kinase 3;MAP kinase 3;MAPK 3;ERT2;Extracellular signal-regulated kinase 1;ERK-1;Insulin-stimulated MAP2 kinase;MAP kinase isoform p44;p44-MAPK;Microtubule-associated protein 2 kinase;p
Organism-1: Human
Gene ID-1: 5594;5595
SwissProt-1: P27361;P28482
Organism-2: Mouse
Gene ID-2: 26417;26413
SwissProt-2: --
Organism-3: Rat
Gene ID-3: 50689;116590
SwissProt-3: P21708;P63086
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm . Nucleus. Membrane, caveola . Cell junction, focal adhesion . Autophosphorylation at Thr-207 promotes nuclear localization (PubMed:19060905). PEA15-binding redirects the biological outcome of MAPK3 kinase-signaling by sequestering MAPK3 into the cytoplasm (By similarity). .