U-Blot® PRC1(Phospho Thr481)Polyclonal Antibody

Name: U-Blot® PRC1(Phospho Thr481)Polyclonal Antibody
SKU: WP10242
Availability: InStock

$288.00

Size:50μL

SKU: WP10242-50

Catalog No.: WP10242

Specification: 50μL/100μL

Stock: In stock

U-Blot® PRC1(Phospho Thr481)Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012],

Product Overview

Catalog No.: WP10242
SKU: WP10242-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: PRC1(Phospho-Thr481)Polyclonal Antibody
Reactivity: Human,Rat,Mouse,
Application: WB,IHC
MW(Calculated): --
MW(Observed): 72kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: WB 1:500-2000;IHC 1:50-300
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthetic Phospho peptide from human protein at AA range: 481
Sequence: --
Specificity: The antibody detects endogenous PRC1Phospho occurs at Thr481
Gene Name: PRC1
Protein Name: Protein regulator of cytokinesis 1
Other Name: Protein regulator of cytokinesis 1
Organism-1: Human
Gene ID-1: 9055
SwissProt-1: O43663
Organism-2: Mouse
Gene ID-2: --
SwissProt-2: Q99K43
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Nucleus . Cytoplasm. Cytoplasm, cytoskeleton, spindle pole . Midbody . Chromosome . Colocalized with KIF20B in the nucleus of bladder carcinoma cells at the interphase. Colocalized with KIF20B in bladder carcinoma cells at prophase, metaphase, early anaphase, at the midzone in late anaphase and at the contractile ring in telophase (PubMed:17409436). Predominantly localized to the nucleus of interphase cells. During mitosis becomes associated with the mitotic spindle poles and localizes with the cell midbody during cytokinesis. Co-localizes with PRC1 in early mitosis and at the spindle midzone from anaphase B to telophase (PubMed:15297875, PubMed:15625105). .