U-Blot® ALK (Phospho Tyr1586) Polyclonal Antibody

Name: U-Blot® ALK (Phospho Tyr1586) Polyclonal Antibody
SKU: WP10260
Availability: InStock

$288.00

Size:50μL

SKU: WP10260-50

Catalog No.: WP10260

Specification: 50μL/100μL

Stock: In stock

U-Blot® ALK (Phospho Tyr1586) Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome

Product Overview

Catalog No.: WP10260
SKU: WP10260-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: ALK
Reactivity: Human:Y1586,Mouse:Y1592
Application: IHC,IF,WB
MW(Calculated): --
MW(Observed): 150-240kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: IHC 1:50-200;WB 1:500-2000;IF 1:50-200
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized peptide derived from human ALK (Phospho-Tyr1586)
Sequence: --
Specificity: This antibody detects endogenous levels of ALK at Human:Y1586; Mouse:Y1592, It doesn't reacte with total protein.
Gene Name: ALK
Protein Name: ALK (Phospho-Tyr1586)
Other Name: ALK;ALK tyrosine kinase receptor;Anaplastic lymphoma kinase;CD antigen CD246
Organism-1: Human
Gene ID-1: 238
SwissProt-1: Q9UM73
Organism-2: --
Gene ID-2: --
SwissProt-2: --
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cell membrane ; Single-pass type I membrane protein . Membrane attachment is essential for promotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinase pathway. .