U-Blot® ATF-2 (Phospho Thr69/71) rabbit pAb

Name: U-Blot® ATF-2 (Phospho Thr69/71) rabbit pAb
SKU: WP10293
Availability: InStock

$288.00

Size:50μL

SKU: WP10293-50

Catalog No.: WP10293

Specification: 50μL/100μL

Stock: In stock

U-Blot® ATF-2 (Phospho Thr69/71) rabbit pAb Learn more

Product details Specifications Q & A Education

Background：activating transcription factor 2(ATF2) Homo sapiens This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014

Product Overview

Catalog No.: WP10293
SKU: WP10293-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: ATF-2
Reactivity: Human,Mouse,Rat
Application: WB
MW(Calculated): --
MW(Observed): 56kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: WB 1:1000-2000
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized phosho peptide around human ATF-2 (Thr69 and 71)
Sequence: --
Specificity: This antibody detects endogenous levels of Human Mouse Rat ATF-2 (phospho-Thr69 or 71)
Gene Name: ATF2 CREB2 CREBP1
Protein Name: ATF-2 (Thr69/71)
Other Name: Cyclic AMP-dependent transcription factor ATF-2;cAMP-dependent transcription factor ATF-2;Activating transcription factor 2;Cyclic AMP-responsive element-binding protein 2;CREB-2;cAMP-responsive element-binding protein 2;HB16;cAMP response element-binding protein CRE-BP1;
Organism-1: Human
Gene ID-1: 1386
SwissProt-1: P15336
Organism-2: Mouse
Gene ID-2: 100047997
SwissProt-2: P16951
Organism-3: Rat
Gene ID-3: 81647
SwissProt-3: Q00969
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Nucleus. Cytoplasm. Mitochondrion outer membrane. Shuttles between the cytoplasm and the nucleus and heterodimerization with JUN is essential for the nuclear localization. Localization to the cytoplasm is observed under conditions of cellular stress and in disease states. Localizes at the mitochondrial outer membrane in response to genotoxic stress. Phosphorylation at Thr-52 is required for its nuclear localization and negatively regulates its mitochondrial localization. Co-localizes with the MRN complex in the IR-induced foci (IRIF).