U-Blot® BMAL1 (Phospho Ser42) rabbit pAb

Name: U-Blot® BMAL1 (Phospho Ser42) rabbit pAb
SKU: WP10305
Availability: InStock

$288.00

Size:50μL

SKU: WP10305-50

Catalog No.: WP10305

Specification: 50μL/100μL

Stock: In stock

U-Blot® BMAL1 (Phospho Ser42) rabbit pAb Learn more

Product details Specifications Q & A Education

Background：The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014],

Product Overview

Catalog No.: WP10305
SKU: WP10305-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: BMAL1
Reactivity: Human,Mouse,Rat
Application: WB
MW(Calculated): --
MW(Observed): 69kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: WB 1:1000-2000
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized phosho peptide around human BMAL1 (Ser42)
Sequence: --
Specificity: This antibody detects endogenous levels of Human Mouse Rat BMAL1 (phospho-Ser42)
Gene Name: ARNTL BHLHE5 BMAL1 MOP3 PASD3
Protein Name: BMAL1 (Ser42)
Other Name: Aryl hydrocarbon receptor nuclear translocator-like protein 1;Basic-helix-loop-helix-PAS protein MOP3;Brain and muscle ARNT-like 1;Class E basic helix-loop-helix protein 5;bHLHe5;Member of PAS protein 3;PAS domain-containing protein 3;bHLH-PAS protein JAP3;
Organism-1: Human
Gene ID-1: 406
SwissProt-1: O00327
Organism-2: Mouse
Gene ID-2: 11865
SwissProt-2: Q9WTL8
Organism-3: Rat
Gene ID-3: 29657
SwissProt-3: Q9EPW1
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Nucleus . Cytoplasm . Nucleus, PML body . Shuttles between the nucleus and the cytoplasm and this nucleocytoplasmic shuttling is essential for the nuclear accumulation of CLOCK, target gene transcription and the degradation of the CLOCK-ARNTL/BMAL1 heterodimer. The sumoylated form localizes in the PML body. Sequestered to the cytoplasm in the presence of ID2. .